Thierry Fredrich, Heiko Rieger, Roberto Chignola, Edoardo Milotti
One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. these evolutionary processes turn the microenvironment into a powerful source of tumour heterogeneity and contribute to the development of drug resistance in cancer. Here, we describe a computational tool to study the ecology of the microenvironment and report results about the ecology of the tumour microenvironment and its evolutionary dynamics.
Fine-grained simulations of the microenvironment of vascularized tumours |
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Scientific Reports 9, 11698 (2019) | [pdf], [arXiv ], [bioRxiv] |
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